var ip = " INFUSE-(Lactated Ringer's) LR Study1:
A randomized, double-blind, placebo-controlled, within-subject trial conducted in two stages. The 54 enrolled subjects were healthy adult volunteers aged 18 to 60 years. In stage 1 (n=5), pilot data was generated comparing Sub-Q infusion to IV; pilot study Sub-Q flow rate with and without hyaluronidase human injection was used to confirm the estimated sample size for stage 2. Stage 2 was powered to definitively assess the Sub-Q flow rate with and without hyaluronidase human injection. Catheters were placed in both upper arms, which were injected with either hyaluronidase human injection or placebo. The primary outcome was comparison of the time to infuse 400 mL LR with or without hyaluronidase human injection. Secondary outcomes included discomfort assessments, edema, arm circumference, arm circumference recovery time, adverse events, and subject/investigator global preference. Published 2007.
1. Thomas JR, Yocum RC, Haller MF, von Gunten CF. Assessing the role of human recombinant hyaluronidase in gravity-driven subcutaneous hydration: the INFUSE-LR study. J Palliat Med. 2007;10(6):1312-1320.
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var ti = " INFUSE-PEDS 1 Study :
The INcreased Flow Utilizing Subcutaneously-Enabled Pediatric Rehydration (INFUSE-Pediatric Rehydration Study) was a single-arm, open-label study and consisted of 51 subjects aged 2 months to 10 years with mild to moderate dehydration as measured by having one to six signs/symptoms on the Gorelick scale. Most of the subjects were younger than 3 years. Publication in press November 2009.
1. Allen C, Etzwiler L, Miller M, Maher G, Mace S. Subcutaneous Fluids Augmented With Recombinant Human Hyaluronidase in Infants and Children With Mild to Moderate Dehydration: The INFUSE-Pediatric Rehydration Study. Pediatrics. 2009; In press.
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var it= " Spandorfer Study 1:
A randomized, controlled clinical trial was performed in the emergency department of an urban children's hospital from December 2001 to April 2003. The main objective of the study was to test the hypothesis that the failure rate of oral rehydration therapy (ORT) would not be more than 5% greater than the failure rate of IV infusion. Secondary objectives were to determine whether the pediatric patients in the ORT group would require less time to initiate therapy, show more improvement after 2 hours of therapy, have fewer hospitalizations, or prefer ORT for future. The study involved 73 moderately dehydrated pediatric patients, ages ranging from 8 weeks to 3 years old. Published 2005.
1. Spandorfer PR, Alessandrini EA, Joffe MD, Localio R, Shaw KN. Oral versus intravenous rehydration of moderately dehydrated children: a randomized, controlled trial. Pediatrics. 2005;115(2):295-301.
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var bs = " Bender Study 1
A prospective case series was designed to test the hypothesis that children who receive IV hydration for gastroenteritis spend significantly less than the American Academy of Pediatrics (AAP) recommended 4-hour ORT in the emergency department. Time spent in treatment was defined as the period elapsed from when a physician placed a patient in the emergency department room to discharge. The series involved a sample of 549 children treated with IV hydration for mild to moderate dehydration at an urban pediatric emergency department. Published 2004.
1. Bender BJ, Ozuah PO. Intravenous rehydration for gastroenteritis: how long does it really take? Pediatr Emerg Care. 2004; 20(4):215-218.
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