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hylenex recombinant-facilitated Sub-Q rehydration—simple rehydration with first-stick access success in today’s busy emergency room.
9 out of 10 (45/49) responding healthcare providers rated hylenex recombinant-facilitated Sub-Q rehydration as being as effective as or more effective than IV therapy.2
About hylenex recombinant
hylenex recombinant (hyaluronidase human injection) is the first and only human recombinant hyaluronidase approved by the U.S. Food and Drug Administration (FDA) for subcutaneous fluid administration.
How hylenex recombinant Works1
- hylenex recombinant is a purified preparation of the enzyme, hyaluronidase.
- Hyaluronidase breaks down hyaluronic acid, a space-filling gel that exists in the subcutaneous (under the skin) tissue.
- hylenex recombinant temporarily makes the tissue beneath the skin more permeable (capable of being passed through) and able to absorb fluid, allowing fluids to be more readily absorbed into the blood vessels.
- Once hylenex recombinant has been given, fluids can be administered subcutaneously.
Role of hylenex recombinant
hylenex recombinant facilitated subcutaneous rehydration represents an alternative to IV administration of fluids.
hylenex recombinant allows fluids to be administered under the skin rather than through a vein, especially when fluid replacement is all that a child needs. Special care must be taken in pediatric patients to avoid over hydration by controlling the rate and total volume of the infusion.1
Use of hylenex recombinant
The safety and efficacy of hylenex recombinant has been demonstrated through clinical trials in healthy adults and pediatric patients. While hylenex recombinant has already been FDA-approved to facilitate subcutaneous fluid administration, clinical research continues to further demonstrate its safety and efficacy, with recent work concentrating on pediatric rehydration. An initial study of the use of hylenex recombinant for pediatric hydration already is complete and data have been accepted for publication. This research shows that hylenex recombinant facilitated subcutaneous rehydration in children with mild to moderate dehydration appears to be safe and effective and well accepted by clinicians and parents.2
1. hylenex recombinant full Prescribing Information
2 Allen C, Etzwiler L, Miller M, Maher G, Mace S. Recombinant Human Hyaluronidase-Enabled Subcutaneous Pediatric Rehydration. PEDIATRICS Volume 124, Number 5, November 2009.
Important Risk Information for Patients
Indication
HYLENEX recombinant is used for subcutaneous fluid administration, the infusion of fluids under the skin
Important Risk Information
- You should not take HYLENEX if you’ve ever had an allergic reaction to products containing hyaluronidase.
- Tell your doctor about all the medications you take, including over the counter medications.
- HYLENEX should not be used to reduce the swelling of bites or stings.
- HYLENEX should not be used near any area that is infected or inflamed.
- The most frequently reported adverse reactions have been mild, local injection site reactions, such as redness, swelling, itching or pain.
- Rarely, patients have reported serious allergic reactions. Seek immediate medical attention if you have an allergic reaction or have trouble swallowing or breathing.
- These are not all of the side effects for HYLENEX. Please contact your doctor for more information.
